Jul 20, 2019 request pdf on researchgate on jan 1, s. Inhibition of hmgcoa reductase, by statins, can re duce the production of. Estos farmacos actuan en las diferentes fases del metabolismo. Hmgcoa reductase inhibitors regulate angiotensin llinduced connective tissue growth factor synthesis. The hmgcoa reductase inhibitors are a class of drugs also known as statins. Hmgcoa reductase inhibitors and myotoxicity springerlink.
The 3hydroxy3methylglutaryl coenzyme a hmg coa reductase inhibitors specifically inhibit hmgcoa reductase in the liver, thereby inhibiting the biosynthesis of cholesterol. Kidney transplant patients experience heart disease more often than the general population. The potential role of hmgcoa reductase inhibitors in. For example, the hmgcoa reductase inhibitors lovastatin and cerivastatin diminish the expression of the integrin dimer cd11b mac1, the cognate ligand of icam1 on endothelium and other cells on monocytes and inhibit adhesion of leukocytes to ecs. Well assume youre ok with this, but you can optout if you wish. The tolerability of these drugs during long term administration. It is a type of hmgcoa reductase inhibitor, a type of statin, and a type of chemosensitizer. Coenzyme a, reductase inhibitors, hydroxymethylglutarylcoa, statin, 3hydroxy3methylglutarylcoenzyme a hmg coa reductase inhibitor, inhib hmg coa reductase, inhib hydroxymethylglutaryl coa, hmg coa. These drugs are effective and widely prescribed for the treatment of hypercholesterolemia and prevention of cardiovascular morbidity and mortality. Hmgcoa reductase inhibitors in the therapy of osteoporosis.
Rhabdomyolysis and hmgcoa reductase inhibitors mohamed. Hmg coa reductase inhibitors statins for kidney transplant recipients. Rhabdomyolysis and hmgcoa reductase inhibitors mohamed a. Nawrocki jw, weiss sr, davidson mh et al reduction of ldlcholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new hmgcoa reductase inhibitor. Estatinas, reductores del colesterol texas heart institute. These drugs significantly reduce plasma cholesterol level and long term treatment reduces morbidity and mortality associated with coronary heart disease. Inflammation, immunity, and hmgcoa reductase inhibitors.